The putative tumor suppressor ZMYND11 recognizes H3.3K36me3

Cancer Discov. 2014 May;4(5):OF12. doi: 10.1158/2159-8290.CD-RW2014-065. Epub 2014 Mar 20.

Abstract

ZMYND11 represses gene expression by binding H3.3K36me3 and preventing transcription elongation.

MeSH terms

  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism*
  • Cell Cycle Proteins
  • Co-Repressor Proteins
  • DNA-Binding Proteins
  • Gene Expression Regulation, Neoplastic
  • Histones / chemistry
  • Histones / metabolism*
  • Humans
  • Neoplasms / genetics
  • Neoplasms / pathology*
  • RNA Polymerase III / metabolism

Substances

  • Carrier Proteins
  • Cell Cycle Proteins
  • Co-Repressor Proteins
  • DNA-Binding Proteins
  • Histones
  • ZMYND11 protein, human
  • RNA Polymerase III