Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment

Mathumai Kanapathipillai; Amy Brock; Donald E Ingber

doi:10.1016/j.addr.2014.05.005

Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment

Adv Drug Deliv Rev. 2014 Dec 15:79-80:107-18. doi: 10.1016/j.addr.2014.05.005. Epub 2014 May 9.

Authors

Mathumai Kanapathipillai¹, Amy Brock², Donald E Ingber³

Affiliations

¹ Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.
² Department of Biomedical Engineering, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX USA.
³ Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA; Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. Electronic address: don.ingber@wyss.harvard.edu.

PMID: 24819216
DOI: 10.1016/j.addr.2014.05.005

Abstract

Nanoparticle-based therapeutics are poised to become a leading delivery strategy for cancer treatment because they potentially offer higher selectivity, reduced toxicity, longer clearance times, and increased efficacy compared to conventional systemic therapeutic approaches. This article reviews existing nanoparticle technologies and methods that are used to target drugs to treat cancer by altering signal transduction or modulating the tumor microenvironment. We also consider the implications of recent advances in the nanotherapeutics field for the future of cancer therapy.

Keywords: Delivery; Drug; Microenvironment; Nanoparticle; Nanotherapeutics; Tumor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / adverse effects
Antineoplastic Agents / therapeutic use
Drug Delivery Systems
Humans
Nanoparticles*
Neoplasms / drug therapy*
Neoplasms / pathology
Signal Transduction / drug effects
Tumor Microenvironment / drug effects

Substances

Antineoplastic Agents