RACK1, a versatile hub in cancer

Oncogene. 2015 Apr 9;34(15):1890-8. doi: 10.1038/onc.2014.127. Epub 2014 Jun 2.

Abstract

RACK1 is a highly conserved intracellular adaptor protein with significant homology to Gβ and was originally identified as the anchoring protein for activated protein kinase C. In the past 20 years, the number of binding partners and validated cellular functions for RACK1 has increased, which facilitates clarification of its involvement in different biological events. In this review, we will focus on its role in cancer, summarizing its aberrant expression, pro- or anti-oncogenic effects and the underlying mechanisms in various cancers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • GTP-Binding Proteins / genetics
  • GTP-Binding Proteins / metabolism*
  • Humans
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Neuropeptides / genetics
  • Neuropeptides / metabolism
  • Receptors for Activated C Kinase
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction

Substances

  • Neoplasm Proteins
  • Neuropeptides
  • RACK1 protein, human
  • RACK1 protein, mouse
  • Receptors for Activated C Kinase
  • Receptors, Cell Surface
  • GTP-Binding Proteins