Abstract
Mutualism with our intestinal microbiota is a prerequisite for healthy existence. This requires physical separation of the majority of the microbiota from the host (by secreted antimicrobials, mucus, and the intestinal epithelium) and active immune control of the low numbers of microbes that overcome these physical and chemical barriers, even in healthy individuals. In this review, we address how B-cell responses to members of the intestinal microbiota form a robust network with mucus, epithelial integrity, follicular helper T cells, innate immunity, and gut-associated lymphoid tissues to maintain host-microbiota mutualism.
Keywords:
B lymphocytes; IgA; gut-associated lymphoid tissue; innate immunity; intestinal barrier; microbiota.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Autophagy
-
B-Lymphocyte Subsets / immunology*
-
B-Lymphocyte Subsets / metabolism
-
Cellular Microenvironment / immunology
-
Endoplasmic Reticulum Stress
-
Fatty Acids / metabolism
-
Histone Deacetylases / metabolism
-
Host-Pathogen Interactions / immunology*
-
Humans
-
IgA Deficiency / genetics
-
IgA Deficiency / immunology
-
IgA Deficiency / microbiology
-
Immune System / physiology*
-
Immunity, Innate
-
Immunity, Mucosal
-
Immunoglobulin A / immunology
-
Immunologic Deficiency Syndromes / genetics
-
Immunologic Deficiency Syndromes / immunology
-
Immunologic Deficiency Syndromes / microbiology
-
Intestinal Mucosa / immunology
-
Intestinal Mucosa / microbiology
-
Intestines / immunology
-
Intestines / microbiology
-
Microbiota / immunology*
-
Mucus / microbiology
-
Mucus / physiology
-
Peyer's Patches / immunology
-
Symbiosis
-
T-Lymphocyte Subsets / immunology
-
T-Lymphocyte Subsets / metabolism
Substances
-
Fatty Acids
-
Immunoglobulin A
-
Histone Deacetylases
Supplementary concepts
-
Immune Deficiency Disease