Speradines F-H, three new oxindole alkaloids from the marine-derived fungus Aspergillus oryzae

Chem Pharm Bull (Tokyo). 2014;62(9):942-6. doi: 10.1248/cpb.c14-00312. Epub 2014 Jun 26.

Abstract

A rare hexacyclic oxindole alkaloid, speradine F (1), together with two novel tetracyclic oxindole alkaloids, speradines G (2) and H (3), were isolated from the marine-derived fungus Aspergillus oryzae. Their structures were determined by spectroscopic methods and X-ray diffraction analysis. This study is the first report on cyclopiazonic acid (CPA)-type alkaloids with a hexacyclic skeleton.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Aspergillus oryzae / chemistry*
  • Fermentation
  • Indoles / chemistry*
  • Marine Biology*
  • Models, Molecular
  • Proton Magnetic Resonance Spectroscopy

Substances

  • Alkaloids
  • Indoles