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IL-7 receptor recovery on CD8 T-cells isolated from HIV+ patients is inhibited by the HIV Tat protein.
PLoS One. 2014 Jul 17;9(7):e102677. doi: 10.1371/journal.pone.0102677. eCollection 2014.
PLoS One. 2014.
PMID: 25033393
Free PMC article.
Soluble HIV Tat protein removes the IL-7 receptor alpha-chain from the surface of resting CD8 T cells and targets it for degradation.
Faller EM, Sugden SM, McVey MJ, Kakal JA, MacPherson PA.
Faller EM, et al.
J Immunol. 2010 Sep 1;185(5):2854-66. doi: 10.4049/jimmunol.0902207. Epub 2010 Jul 26.
J Immunol. 2010.
PMID: 20660706
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IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells.
Faller E, Kakal J, Kumar R, Macpherson P.
Faller E, et al.
Int Immunol. 2009 Mar;21(3):203-16. doi: 10.1093/intimm/dxn140. Epub 2009 Jan 15.
Int Immunol. 2009.
PMID: 19147839
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Interleukin-7 receptor expression on CD8 T-cells is downregulated by the HIV Tat protein.
Faller EM, McVey MJ, Kakal JA, MacPherson PA.
Faller EM, et al.
J Acquir Immune Defic Syndr. 2006 Nov 1;43(3):257-69. doi: 10.1097/01.qai.0000230319.78288.f4.
J Acquir Immune Defic Syndr. 2006.
PMID: 16967044
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