Advances in epigenome-wide association studies for common diseases

Trends Mol Med. 2014 Oct;20(10):541-3. doi: 10.1016/j.molmed.2014.07.002. Epub 2014 Aug 1.

Abstract

Epigenome-wide association studies (EWASs) provide a systematic approach to uncovering epigenetic variants underlying common diseases. Discoveries have shed light on novel molecular mechanisms of disease and enabled the application of epigenetic variants as biomarkers. Here, we highlight the recent advances in this emerging line of research and discuss key challenges for current and future studies.

Keywords: DNA methylation; EWAS; GWAS; biomarker; disease mechanism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Rheumatoid / genetics
  • Biomarkers
  • DNA Methylation
  • Epigenesis, Genetic*
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study / methods*
  • Genome-Wide Association Study / standards
  • Humans
  • Multiple Sclerosis / genetics

Substances

  • Biomarkers