Levels of soluble TREM-like transcript 1 in patients presenting to the emergency department with chest pain

Clin Appl Thromb Hemost. 2015 Jan;21(1):30-4. doi: 10.1177/1076029614547298. Epub 2014 Aug 21.

Abstract

Objective: Recent studies suggest that the soluble triggering receptor expressed on myeloid cells-like transcript 1 (sTLT-1) facilitate atherothrombosis. Therefore, we evaluated sTLT-1 as a functional measure of atherothrombosis in acute coronary syndrome (ACS).

Methods: Levels of sTLT-1 were determined by enzyme-linked immunosorbent assay on plasma from patients with potential ACS and compared with an age-matched control group with similar risk factors for cardiovascular disease.

Results: Of 53 patients enrolled, 19 patients were undergoing ACS (15 unstable angina, 2 non-ST-segment elevated myocardial infarction, and 2 ST-segment elevated myocardial infarction), 5 patients were found with noncardiac chest pain, and 29 were in the control group. The mean plasma sTLT-1 values in the ACS group were 4.644 ng/mL ± 1.277 standard error of the mean (SEM), in the noncardiac chest pain group were 0.708 ng/mL ± 0.427 SEM, and in the control group were 1.007 ng/mL ± 0.098 SEM.

Conclusion: A statistically significant difference exists between patients experiencing cardiogenic chest pain versus controls (P < .05), suggesting sTLT-1 as a potential tool for understanding atherothrombosis in ACS.

Keywords: TREM; acute coronary syndromes; atherosclerosis; cardiology; lupus inhibitor; sTLT-1.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acute Coronary Syndrome / blood*
  • Acute Coronary Syndrome / diagnosis*
  • Acute Coronary Syndrome / etiology
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Blood Platelets / physiology
  • Case-Control Studies
  • Chest Pain / blood*
  • Chest Pain / etiology
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / complications
  • Emergency Service, Hospital
  • Female
  • Humans
  • Inflammation Mediators / blood
  • Male
  • Middle Aged
  • Receptors, Immunologic / blood*
  • Risk Factors
  • Solubility

Substances

  • Biomarkers
  • Inflammation Mediators
  • Receptors, Immunologic
  • TREML1 protein, human