Abstract
We report a probable interaction between a vitamin K antagonist, fluindione, and the herbal medicine turmeric that resulted in the elevation of the international normalized ratio (INR). The case presented here underlines the importance of considering potential exposure to herbal medications when assessing adverse effects.
© 2014 Société Française de Pharmacologie et de Thérapeutique.
MeSH terms
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4-Hydroxycoumarins / administration & dosage
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4-Hydroxycoumarins / adverse effects*
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Administration, Oral
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Anticoagulants / administration & dosage
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Anticoagulants / adverse effects*
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Curcuma / adverse effects*
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Female
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Hemorrhage / chemically induced*
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Herb-Drug Interactions*
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Humans
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Indenes / administration & dosage
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Indenes / adverse effects*
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International Normalized Ratio
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Middle Aged
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Mitral Valve Insufficiency / drug therapy*
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Phenindione / administration & dosage
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Phenindione / adverse effects
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Phenindione / analogs & derivatives*
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Vitamin K / administration & dosage
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Vitamin K / adverse effects
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Vitamin K / antagonists & inhibitors*
Substances
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4-Hydroxycoumarins
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Anticoagulants
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Indenes
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antivitamins K
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Vitamin K
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Phenindione
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fluindione