Probable interaction between an oral vitamin K antagonist and turmeric (Curcuma longa)

Therapie. 2014 Nov-Dec;69(6):519-20. doi: 10.2515/therapie/2014062. Epub 2014 Sep 18.

Abstract

We report a probable interaction between a vitamin K antagonist, fluindione, and the herbal medicine turmeric that resulted in the elevation of the international normalized ratio (INR). The case presented here underlines the importance of considering potential exposure to herbal medications when assessing adverse effects.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • 4-Hydroxycoumarins / administration & dosage
  • 4-Hydroxycoumarins / adverse effects*
  • Administration, Oral
  • Anticoagulants / administration & dosage
  • Anticoagulants / adverse effects*
  • Curcuma / adverse effects*
  • Female
  • Hemorrhage / chemically induced*
  • Herb-Drug Interactions*
  • Humans
  • Indenes / administration & dosage
  • Indenes / adverse effects*
  • International Normalized Ratio
  • Middle Aged
  • Mitral Valve Insufficiency / drug therapy*
  • Phenindione / administration & dosage
  • Phenindione / adverse effects
  • Phenindione / analogs & derivatives*
  • Vitamin K / administration & dosage
  • Vitamin K / adverse effects
  • Vitamin K / antagonists & inhibitors*

Substances

  • 4-Hydroxycoumarins
  • Anticoagulants
  • Indenes
  • antivitamins K
  • Vitamin K
  • Phenindione
  • fluindione