Absence of interleukin-1 receptor 1 increases excitatory and inhibitory scaffolding protein expression and microglial activation in the adult mouse hippocampus

Cell Mol Immunol. 2015 Sep;12(5):645-7. doi: 10.1038/cmi.2014.87. Epub 2014 Sep 29.

Authors

Una Avdic^{1

2}, Deepti Chugh^{1

2}, Harer Osman¹, Katie Chapman³, Johanna Jackson^{1

4}, Christine T Ekdahl^{1

2}

Affiliations

¹ Inflammation and Stem Cell Therapy Group, Division of Clinical Neurophysiology, Lund University, Lund, Sweden.
² Lund Epilepsy Center, Lund University, Lund, Sweden.
³ Current address: Division of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden.
⁴ Current address: Lilly UK, Windlesham, Surrey, UK.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aging / metabolism*
Animals
Carrier Proteins / metabolism*
Cell Nucleus / metabolism
Disks Large Homolog 4 Protein
Guanylate Kinases / metabolism*
Hippocampus / metabolism*
Membrane Proteins / metabolism*
Mice, Knockout
Microglia / metabolism*
Receptors, Interleukin-1 / deficiency*
Receptors, Interleukin-1 / metabolism
Signal Transduction

Substances

Carrier Proteins
Disks Large Homolog 4 Protein
Dlg4 protein, mouse
Membrane Proteins
Receptors, Interleukin-1
gephyrin
Guanylate Kinases