Potentiality of the "Gum Metal" titanium-based alloy for biomedical applications

Mater Sci Eng C Mater Biol Appl. 2014 Nov:44:362-70. doi: 10.1016/j.msec.2014.08.003. Epub 2014 Aug 7.

Abstract

In this study, the "Gum Metal" titanium-based alloy (Ti-23Nb-0.7Ta-2Zr-1.2O) was synthesized by melting and then characterized in order to evaluate its potential for biomedical applications. Thus, the mechanical properties, the corrosion resistance in simulated body fluid and the in vitro cell response were investigated. It was shown that this alloy presents a very high strength, a low Young's modulus and a high recoverable strain by comparison with the titanium alloys currently used in medicine. On the other hand, all electrochemical and corrosion parameters exhibited more favorable values showing a nobler behavior and negligible toxicity in comparison with the commercially pure Ti taken as reference. Furthermore, the biocompatibility tests showed that this alloy induced an excellent response of MC3T3-E1 pre-osteoblasts in terms of attachment, spreading, viability, proliferation and differentiation. Consequently, the "Gum Metal" titanium-based alloy processes useful characteristics for the manufacturing of highly biocompatible medical devices.

Keywords: Biocorrosion; Cytocompatibility; Mechanical properties; Titanium alloy.

MeSH terms

  • 3T3-L1 Cells
  • Alloys / chemistry
  • Animals
  • Biocompatible Materials / chemistry*
  • Body Fluids / drug effects
  • Cell Differentiation / drug effects
  • Cell Proliferation / drug effects
  • Elastic Modulus / drug effects
  • Electrochemical Techniques
  • Materials Testing / methods
  • Mice
  • Osteoblasts / drug effects
  • Titanium / chemistry*
  • Titanium / pharmacology

Substances

  • Alloys
  • Biocompatible Materials
  • Titanium