Following surgery of cholesteatoma, a patient developed a chronic infection of the external auditory canal, including extended-spectrum β-lactamase producing Escherichia coli, which caused severe pain. The application of cold atmospheric plasma resulted in a significant reduction in pain and clearance of bacterial carriage, allowing antibiotics and analgesics to be ceased.
Keywords: (ESBL+) E. coli; Cholesteatoma; cold argon plasma; external auditory canal; plasma; tissue tolerable plasma.