Abstract
This systematic literature review describes the epidemiology of dengue disease in Mexico (2000-2011). The annual number of uncomplicated dengue cases reported increased from 1,714 in 2000 to 15,424 in 2011 (incidence rates of 1.72 and 14.12 per 100,000 population, respectively). Peaks were observed in 2002, 2007, and 2009. Coastal states were most affected by dengue disease. The age distribution pattern showed an increasing number of cases during childhood, a peak at 10-20 years, and a gradual decline during adulthood. All four dengue virus serotypes were detected. Although national surveillance is in place, there are knowledge gaps relating to asymptomatic cases, primary/secondary infections, and seroprevalence rates of infection in all age strata. Under-reporting of the clinical spectrum of the disease is also problematic. Dengue disease remains a serious public health problem in Mexico.
Publication types
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Research Support, Non-U.S. Gov't
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Review
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Systematic Review
MeSH terms
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Age Distribution
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Dengue / epidemiology*
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Dengue Virus / classification*
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Dengue Virus / immunology
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Humans
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Incidence
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Mexico / epidemiology
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Seasons
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Seroepidemiologic Studies
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Serogroup
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Sex Distribution
Grants and funding
Sanofi Pasteur sponsored this survey and analysis. The sponsors of this study formed part of the literature review group. The role of the sponsors in study design, data collection and analysis, decision to publish and preparation of the manuscript is detailed below. The literature review group, which included members of Sanofi Pasteur, were involved in the conception of the literature analysis, development of the protocol, data collection, analysis and interpretation of data, provision of critical comments, writing the paper and approving the final version to be published. All authors were involved in the decision to submit this paper for publication in PLOS NTD.