Immunologic basis for allopurinol-induced severe cutaneous adverse reactions: HLA-B*58:01-restricted activation of drug-specific T cells and molecular interaction

J Allergy Clin Immunol. 2015 Apr;135(4):1063-1065.e5. doi: 10.1016/j.jaci.2014.09.041. Epub 2014 Nov 11.

¹ Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
² Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
³ Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
⁴ Center of Gout, Country Hospital, Taipei, Taiwan.
⁵ Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Infection and Immunity Research Center, National Yang-Ming University, Taipei, Taiwan. Electronic address: sihung@ym.edu.tw.
⁶ Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Electronic address: chen0010@ibms.sinica.edu.tw.

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