Altered mTORC1 signaling in multipotent stem cells from nearly 25% of patients with nonsyndromic autism spectrum disorders

Mol Psychiatry. 2015 May;20(5):551-2. doi: 10.1038/mp.2014.175. Epub 2015 Jan 13.
No abstract available

Publication types

  • Letter

MeSH terms

  • Androstadienes / pharmacology
  • Autism Spectrum Disorder / pathology*
  • Case-Control Studies
  • Cell Differentiation / drug effects
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Child
  • Culture Media, Serum-Free / pharmacology
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / pharmacology
  • Gene Expression Regulation / drug effects
  • Gene Expression Regulation / physiology*
  • Humans
  • Immunosuppressive Agents / pharmacology
  • Male
  • Mechanistic Target of Rapamycin Complex 1
  • Multipotent Stem Cells / drug effects
  • Multipotent Stem Cells / metabolism*
  • Multiprotein Complexes / metabolism*
  • Phosphorylation / drug effects
  • Serum / metabolism
  • Signal Transduction / drug effects
  • Signal Transduction / physiology*
  • Sirolimus / pharmacology
  • TOR Serine-Threonine Kinases / metabolism*
  • Time Factors
  • Wortmannin

Substances

  • Androstadienes
  • Culture Media, Serum-Free
  • Enzyme Inhibitors
  • Immunosuppressive Agents
  • Multiprotein Complexes
  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases
  • Sirolimus
  • Wortmannin