CYP2C19*2 genotype influence in acute coronary syndrome patients undergoing serial clopidogrel dose tailoring based on platelet function testing: Analysis from randomized controlled trial NCT02096419

Int J Cardiol. 2015:186:282-5. doi: 10.1016/j.ijcard.2015.03.171. Epub 2015 Mar 17.
No abstract available

Keywords: Acute coronary syndrome; CYP2C19; Clopidogrel; Pharmacogenetics; Platelet function testing; Tailoring therapy.

Publication types

  • Letter

MeSH terms

  • Acute Coronary Syndrome / blood
  • Acute Coronary Syndrome / drug therapy
  • Acute Coronary Syndrome / genetics*
  • Aged
  • Blood Platelets / physiology*
  • Clopidogrel
  • Cytochrome P-450 CYP2C19 / genetics*
  • Cytochrome P-450 CYP2C19 / metabolism
  • Dose-Response Relationship, Drug
  • Electrocardiography
  • Female
  • Follow-Up Studies
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Platelet Aggregation Inhibitors / administration & dosage
  • Platelet Function Tests
  • Randomized Controlled Trials as Topic
  • Ticlopidine / administration & dosage
  • Ticlopidine / analogs & derivatives*
  • Treatment Outcome

Substances

  • Platelet Aggregation Inhibitors
  • Clopidogrel
  • Cytochrome P-450 CYP2C19
  • Ticlopidine