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Cell Metab. 2015 Apr 7;21(4):622-7. doi: 10.1016/j.cmet.2015.03.003.

GATM polymorphism associated with the risk for statin-induced myopathy does not replicate in case-control analysis of 715 dyslipidemic individuals.

Author information

1
Center for Pharmacogenomics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: luzum.2@osu.edu.
2
Center for Pharmacogenomics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
3
Department of Pediatrics, University at Buffalo, Buffalo, NY 14214, USA.
4
Department of Biostatistics, University at Buffalo, Buffalo, NY 14214, USA.
5
Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
6
Center for Pharmacogenomics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
7
Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY 14214, USA.
8
Departments of Pediatrics, Neurology, and Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY 14214, USA.

Abstract

Statin-induced myopathy (SIM) is the most common reason for discontinuation of statin therapy. A polymorphism affecting the gene encoding glycine amidinotransferase (GATM rs9806699 G > A) was previously associated with reduced risk for SIM. Our objective was to replicate the GATM association in a large, multicenter SIM case-control study. Mild and severe SIM cases and age- and gender-matched controls were enrolled. Participants were genotyped, and associations were tested (n = 715) using chi-square and logistic regression with consideration for SIM severity and exclusion of subjects with potentially confounding comedications. The minor allele (A) frequencies of GATM rs9806699 in the controls (n = 106), mild SIM (n = 324), and severe SIM (n = 285) cases were 0.26, 0.28, and 0.29, respectively (p = 0.447). The unadjusted odds ratio for the A allele for any SIM (mild or severe) was 1.14 (0.82-1.61; p = 0.437), which remained nonsignificant in all models. Our results do not replicate the association between GATM rs9806699 and SIM.

PMID:
25863251
PMCID:
PMC4394188
DOI:
10.1016/j.cmet.2015.03.003
[Indexed for MEDLINE]
Free PMC Article

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