Abstract
A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction.
Keywords:
MMPs; enzyme-responsive; intravenous injection; myocardial infarction; nanoparticles.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Disease Models, Animal
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Drug Carriers / chemistry*
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Drug Delivery Systems / methods
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Dynamic Light Scattering
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Fluorescence
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Heart / drug effects*
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Hydrophobic and Hydrophilic Interactions
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Injections, Intravenous
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Matrix Metalloproteinase 2 / metabolism*
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Matrix Metalloproteinase 9 / metabolism*
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Micelles
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Myocardial Infarction / drug therapy*
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Myocardial Infarction / enzymology
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Myocardium / enzymology
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Nanoparticles / chemistry*
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Polymers / chemistry
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Rats
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Time Factors
Substances
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Drug Carriers
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Micelles
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Polymers
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Matrix Metalloproteinase 2
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Mmp2 protein, rat
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Matrix Metalloproteinase 9
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Mmp9 protein, rat