Oxidation of NADH and ROS production by respiratory complex I

Biochim Biophys Acta. 2016 Jul;1857(7):863-71. doi: 10.1016/j.bbabio.2015.11.004. Epub 2015 Nov 10.

Abstract

Kinetic characteristics of the proton-pumping NADH:quinone reductases (respiratory complexes I) are reviewed. Unsolved problems of the redox-linked proton translocation activities are outlined. The parameters of complex I-mediated superoxide/hydrogen peroxide generation are summarized, and the physiological significance of mitochondrial ROS production is discussed. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt.

Keywords: Bacterial plasma membranes; Hydrogen peroxide; Mitochondria; NADH:quinone oxidoreductase; Proton pumping; Superoxide.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Electron Transport
  • Electron Transport Complex I / chemistry*
  • Electron Transport Complex I / ultrastructure*
  • Enzyme Activation
  • Models, Chemical
  • Molecular Dynamics Simulation
  • NAD / chemistry*
  • NAD / ultrastructure
  • Oxidation-Reduction
  • Protein Conformation
  • Proton Pumps / chemistry*
  • Proton Pumps / ultrastructure*
  • Reactive Oxygen Species / chemical synthesis*

Substances

  • Proton Pumps
  • Reactive Oxygen Species
  • NAD
  • Electron Transport Complex I