Treatment with anti-cytokine monoclonal antibodies can potentiate the target cytokine rather than neutralize its activity

Allergy. 2016 Mar;71(3):283-5. doi: 10.1111/all.12816.

Authors

C D Rudulier¹, M Larché², D Moldaver²

Affiliations

¹ Division of Respirology, Critical Care and Sleep Medicine, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
² Divisions of Respirology and Clinical Immunology and Allergy, Department of Medicine, McMaster Immunology Research Centre, Firestone Institute for Respiratory Health, St. Joseph's Healthcare, McMaster University, Hamilton, Ontario, Canada.

PMID: 26619376
DOI: 10.1111/all.12816

No abstract available

Publication types

News
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Monoclonal / immunology
Antibodies, Monoclonal / metabolism*
Antibodies, Monoclonal / pharmacology*
Antibodies, Monoclonal / therapeutic use
Antibodies, Neutralizing / immunology
Antibodies, Neutralizing / metabolism
Antibodies, Neutralizing / pharmacology
Antigen-Antibody Complex / metabolism
Cytokines / agonists
Cytokines / antagonists & inhibitors*
Cytokines / metabolism*
Humans

Substances

Antibodies, Monoclonal
Antibodies, Neutralizing
Antigen-Antibody Complex
Cytokines