Abstract
Cellular senescence of endothelial cells plays an important role in the development of vascular lesions that ultimately lead to an atherosclerotic plaque. This review focuses on the age-related changes of endothelial and vascular smooth muscle cells that contribute to vascular disease and discusses potential new targets that could rejuvenate the vascular system and thereby prevent or delay atherosclerosis.
Keywords:
aging; atherosclerosis; cellular senescence; endothelium; modified MRNA; prevention; telomerase.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Age Factors
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Animals
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Atherosclerosis / enzymology
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Atherosclerosis / genetics
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Atherosclerosis / pathology
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Atherosclerosis / physiopathology
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Atherosclerosis / prevention & control*
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Cellular Senescence*
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Endothelial Cells / enzymology*
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Endothelial Cells / pathology
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Endothelium, Vascular / enzymology*
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Endothelium, Vascular / pathology
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Endothelium, Vascular / physiopathology
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Enzyme Induction
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Genetic Therapy / methods*
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Humans
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Plaque, Atherosclerotic
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Regeneration*
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Signal Transduction
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Telomerase / biosynthesis
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Telomerase / genetics
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Telomerase / metabolism*