Abstract
Scar formation, with persistent alteration of the normal tissue structure, is an undesirable and significant result of both wound healing and fibrosing disorders. There are few strategies to prevent or to treat scarring. The transforming growth factor beta (TGF-β) superfamily is an important mediator of tissue repair. Each TGF-β isoform may exert a different effect on wound healing, which may be context-dependent. In particular, TGF-β1 may mediate fibrosis in adults' wounds, while TGF-β3 may promote scarless healing in the fetus and reduced scarring in adults. Thus, TGF-β3 may offer a scar-reducing therapy for acute and chronic wounds and fibrosing disorders.
© 2016 by the Wound Healing Society.
MeSH terms
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Cicatrix / prevention & control*
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Fibrosis / pathology
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Fibrosis / therapy*
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Humans
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Intercellular Signaling Peptides and Proteins
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Protein Isoforms
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Scleroderma, Systemic / pathology
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Scleroderma, Systemic / therapy*
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Skin Physiological Phenomena
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Transforming Growth Factor beta / metabolism*
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Transforming Growth Factor beta / therapeutic use*
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Transforming Growth Factor beta1 / metabolism
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Transforming Growth Factor beta1 / therapeutic use
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Transforming Growth Factor beta3 / metabolism
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Transforming Growth Factor beta3 / therapeutic use
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Wound Healing / physiology*
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Wounds and Injuries / pathology
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Wounds and Injuries / therapy*
Substances
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Intercellular Signaling Peptides and Proteins
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Protein Isoforms
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Transforming Growth Factor beta
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Transforming Growth Factor beta1
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Transforming Growth Factor beta3