Abstract
The 2-aminothiazole (2-AT) core is an active pharmacophore and used in medicinal chemistry and drug discovery research. A number of drugs with 2-AT core are in the market, e.g. Famotidine, Cefdinir, Meloxcam etc. Recently, 2-AT core has been explored for many more important therapeutic areas and identified new 2-aminothiazoles with anticancer, antitumor, antidiebatic and anticonvulsant activity. In this review, we discuss the newly identified and developed 2-aminothiazoles in recent years and their use in medicinal chemistry and pharmacology.
Keywords:
2-Aminothiazole; Bioactive; Drugs; Medicinal chemistry; Pharmacological activity; Review; Thiazole.
Copyright © 2015 Elsevier Masson SAS. All rights reserved.
MeSH terms
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Animals
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology
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Anticonvulsants / chemistry
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Anticonvulsants / pharmacology
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Antihypertensive Agents / chemistry
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Antihypertensive Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Drug Discovery* / methods
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Humans
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / pharmacology
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Structure-Activity Relationship
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Thiazoles / chemistry*
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Thiazoles / pharmacology*
Substances
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Anti-Infective Agents
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Anti-Inflammatory Agents
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Anticonvulsants
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Antihypertensive Agents
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Antineoplastic Agents
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Hypoglycemic Agents
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Neuroprotective Agents
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Thiazoles
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2-aminothiazole