ISAba1/blaOXA-23: A serious obstacle to controlling the spread and treatment of Acinetobacter baumannii strains

Am J Infect Control. 2016 May 1;44(5):593-5. doi: 10.1016/j.ajic.2015.11.020. Epub 2016 Jan 21.

Abstract

This study demonstrated a direct correlation between Acinetobacter baumannii clusters carrying the ISAba1/blaOXA-23 gene and increased minimal inhibitory concentrations for carbapenems and greater clonal diversity. Our findings showed that clusters carrying ISAba1 are widely distributed in our hospital, further complicating the treatment and control of infections caused by A baumannii.

Keywords: Acinetobacter baumannii; bla(OXA-23) gene; carbapenems; insertion sequence; resistance.

MeSH terms

  • Acinetobacter Infections / epidemiology*
  • Acinetobacter Infections / microbiology
  • Acinetobacter baumannii / enzymology*
  • Acinetobacter baumannii / genetics*
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics*
  • Carbapenems / pharmacology
  • Cross Infection / epidemiology*
  • Cross Infection / microbiology
  • Genetic Variation
  • Genotype*
  • Hospitals
  • Humans
  • Microbial Sensitivity Tests
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • beta-Lactamases
  • beta-lactamase OXA-23, Acinetobacter baumannii