Shared Risk Factors in Cardiovascular Disease and Cancer

Ryan J Koene; Anna E Prizment; Anne Blaes; Suma H Konety

doi:10.1161/CIRCULATIONAHA.115.020406

Shared Risk Factors in Cardiovascular Disease and Cancer

Circulation. 2016 Mar 15;133(11):1104-14. doi: 10.1161/CIRCULATIONAHA.115.020406.

Authors

Ryan J Koene¹, Anna E Prizment², Anne Blaes², Suma H Konety²

Affiliations

¹ From Department of Medicine, Division of Cardiovascular Medicine, University of Minnesota, Minneapolis (R.J.K., S.H.K.); Department of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.E.P.); Department of Medicine, Division of Oncology, University of Minnesota, Minneapolis (A.B.); and Masonic Cancer Center, University of Minnesota, Minneapolis (A.E.P.). koene030@umn.edu.
² From Department of Medicine, Division of Cardiovascular Medicine, University of Minnesota, Minneapolis (R.J.K., S.H.K.); Department of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.E.P.); Department of Medicine, Division of Oncology, University of Minnesota, Minneapolis (A.B.); and Masonic Cancer Center, University of Minnesota, Minneapolis (A.E.P.).

Abstract

Cardiovascular disease (CVD) and cancer are the 2 leading causes of death worldwide. Although commonly thought of as 2 separate disease entities, CVD and cancer possess various similarities and possible interactions, including a number of similar risk factors (eg, obesity, diabetes mellitus), suggesting a shared biology for which there is emerging evidence. Although chronic inflammation is an indispensable feature of the pathogenesis and progression of both CVD and cancer, additional mechanisms can be found at their intersection. Therapeutic advances, despite improving longevity, have increased the overlap between these diseases, with millions of cancer survivors now at risk of developing CVD. Cardiac risk factors have a major impact on subsequent treatment-related cardiotoxicity. In this review, we explore the risk factors common to both CVD and cancer, highlighting the major epidemiological studies and potential biological mechanisms that account for them.

Keywords: cardiology; cardiovascular diseases; clinical oncology; risk factors.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Adult
Age Factors
Aged
Alcohol Drinking / adverse effects
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Anticarcinogenic Agents / therapeutic use
Antihypertensive Agents / adverse effects
Antihypertensive Agents / therapeutic use
Cardiovascular Diseases / epidemiology*
Cardiovascular Diseases / etiology
Cardiovascular Diseases / prevention & control
Comorbidity
Diabetes Mellitus / epidemiology
Diet / adverse effects
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Hyperinsulinism / epidemiology
Hyperlipidemias / epidemiology
Hypertension / epidemiology
Hypoglycemic Agents / adverse effects
Hypoglycemic Agents / therapeutic use
Inflammation / epidemiology
Male
Middle Aged
Motor Activity
Neoplasms / epidemiology*
Neoplasms / etiology
Neoplasms / prevention & control
Obesity / epidemiology
Oxidative Stress
Risk Factors
Smoking / epidemiology
United States / epidemiology

Substances

Anti-Inflammatory Agents, Non-Steroidal
Anticarcinogenic Agents
Antihypertensive Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypoglycemic Agents

Grants and funding

UL1 TR000114/TR/NCATS NIH HHS/United States