Abstract
Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function, but is also an important component of the tumour microenvironment as it alters the extracellular matrix, modulates the tumour immune response and increases angiogenesis. Here we discuss the regulation and role of hypoxia and its key transcriptional mediators, the hypoxia-inducible factor (HIF) family of transcription factors, in the tumour microenvironment and stromal compartments.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Basic Helix-Loop-Helix Transcription Factors / genetics
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Basic Helix-Loop-Helix Transcription Factors / metabolism*
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Gene Expression Regulation, Neoplastic
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Humans
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Hypoxia
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Hypoxia-Inducible Factor 1 / genetics
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Hypoxia-Inducible Factor 1 / metabolism*
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Models, Biological
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Neoplasms / blood supply
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Neoplasms / genetics
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Neoplasms / metabolism*
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Neovascularization, Pathologic / genetics
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Neovascularization, Pathologic / metabolism*
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Signal Transduction / genetics
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Tumor Microenvironment / genetics
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Hypoxia-Inducible Factor 1
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endothelial PAS domain-containing protein 1