Euglycemic diabetic ketoacidosis induced by SGLT2 inhibitors: possible mechanism and contributing factors

Wataru Ogawa; Kazuhiko Sakaguchi

doi:10.1111/jdi.12401

Euglycemic diabetic ketoacidosis induced by SGLT2 inhibitors: possible mechanism and contributing factors

J Diabetes Investig. 2016 Mar;7(2):135-8. doi: 10.1111/jdi.12401. Epub 2015 Sep 6.

Authors

Wataru Ogawa¹, Kazuhiko Sakaguchi¹

Affiliation

¹ Division of Diabetes and Endocrinology Department of Internal Medicine Kobe University Graduate School of Medicine Kobe Japan.

Abstract

It is possible that SGLT2 inhibitors trigger euglycemic diabetic ketoacidosis in some patients. Possible mechanism of euglycemic DKA induced by SGLT2 inhibitors is illustrated.

Publication types

Editorial

MeSH terms

Blood Glucose
Diabetic Ketoacidosis / chemically induced*
Humans
Hypoglycemic Agents / adverse effects*
Hypoglycemic Agents / pharmacology
Metabolic Networks and Pathways / drug effects
Sodium-Glucose Transporter 2
Sodium-Glucose Transporter 2 Inhibitors*

Substances

Blood Glucose
Hypoglycemic Agents
SLC5A2 protein, human
Sodium-Glucose Transporter 2
Sodium-Glucose Transporter 2 Inhibitors