Rasburicase-induced methemoglobinemia: case report, literature review, and proposed treatment algorithm

Clin Case Rep. 2016 Feb 3;4(4):315-9. doi: 10.1002/ccr3.495. eCollection 2016 Apr.

Abstract

Rasburicase for the treatment of tumor lysis syndrome has been associated with hemolytic anemia and methemoglobinemia, usually in patients with G6PD deficiency. Risks and benefits should be considered prior to use of rasburicase in at-risk patients. Methylene blue will worsen the hemolytic anemia in G6PD deficiency and should be avoided.

Keywords: Hemolytic anemia; methemoglobinemia; rasburicase; tumor lysis syndrome.

Publication types

  • Case Reports