The conversion of fibrinogen to fibrin: A brief history of some key events

Matrix Biol. 2017 Jul:60-61:5-7. doi: 10.1016/j.matbio.2016.08.002. Epub 2016 Aug 9.

Abstract

The conversion of fibrinogen to fibrin is a process that has long fascinated an army of researchers. In this brief review some early break-through observations are noted and a few later unexpected results described.

Keywords: Factor XIII; Fibrin; Fibrinogen; Papain; Protofibrinogen; Thrombin.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • Blood Coagulation / physiology*
  • Ciona intestinalis / chemistry
  • Ciona intestinalis / physiology
  • Factor XIII / chemistry
  • Factor XIII / history
  • Factor XIII / metabolism*
  • Fibrin / chemistry
  • Fibrin / history
  • Fibrin / metabolism*
  • Fibrinogen / chemistry
  • Fibrinogen / history
  • Fibrinogen / metabolism*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Models, Molecular
  • Phase Transition
  • Proteolysis
  • Static Electricity
  • Thrombin / chemistry
  • Thrombin / history
  • Thrombin / metabolism*

Substances

  • Fibrin
  • Fibrinogen
  • Factor XIII
  • Thrombin