Peculiarities of data interpretation upon direct tissue analysis by Fourier transform ion cyclotron resonance mass spectrometry

Eur J Mass Spectrom (Chichester). 2016;22(3):123-6. doi: 10.1255/ejms.1425.

Abstract

The importance of high-resolution mass spectrometry for the correct data interpretation of a direct tissue analysis is demonstrated with an example of its clinical application for an endometriosis study. Multivariate analysis of the data discovers lipid species differentially expressed in different tissues under investigation. High-resolution mass spectrometry allows unambiguous separation of peaks with close masses that correspond to proton and sodium adducts of phosphatidylcholines and to phosphatidylcholines differing in double bond number.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Biomarkers / analysis
  • Computer Simulation
  • Cyclotrons
  • Data Interpretation, Statistical
  • Female
  • Humans
  • Lipids / analysis*
  • Lipids / chemistry
  • Models, Statistical*
  • Multivariate Analysis
  • Ovarian Cysts / chemistry*
  • Ovarian Cysts / diagnosis*
  • Protons
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Sodium / chemistry
  • Spectrometry, Mass, Electrospray Ionization / methods*
  • Tissue Array Analysis / methods

Substances

  • Biomarkers
  • Lipids
  • Protons
  • Sodium