Abstract
Chemical analysis, antimicrobial activity and cytotoxic effects of essential oils (EOs) from leaves of Piper aduncum var. ossanum from two localities Bauta (EO-B) and Ceiba (EO-C), Artemisa Province, Cuba, were determined. EOs were obtained by hydrodistillation and analyzed by gas chromatography/mass spectrometry. EO-B demonstrated higher activity against S. aureus and L. amazonensis; while a lower cytotoxicity on mammalian cells was observed. Both EOs displayed the same activity against Plasmodium falciparum, Trypanosoma cruzi, Trypanosoma brucei, and Leishmania infantum. Both EOs were inactive against Escherichia coli and Candida albicans.
Keywords:
Antimicrobial activities; Antiparasitic activities; Chemodiversity; Cytotoxicities; Essential oils.
© 2016 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology*
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Antiparasitic Agents / chemistry
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Antiparasitic Agents / isolation & purification
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Antiparasitic Agents / pharmacology*
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Candida albicans / drug effects
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Cell Line
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Cell Survival / drug effects
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Cytotoxins / chemistry
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Cytotoxins / isolation & purification
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Cytotoxins / pharmacology*
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Dose-Response Relationship, Drug
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Escherichia coli / drug effects
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Humans
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Leishmania infantum / drug effects
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Macrophages / drug effects
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Mice
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Microbial Sensitivity Tests
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Oils, Volatile / chemistry
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Oils, Volatile / isolation & purification
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Oils, Volatile / pharmacology*
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Oils, Volatile / toxicity*
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Parasitic Sensitivity Tests
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Piper / chemistry*
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Plant Leaves / chemistry
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Plasmodium falciparum / drug effects
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Structure-Activity Relationship
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Trypanosoma / drug effects
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Antiparasitic Agents
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Cytotoxins
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Oils, Volatile