Polymorphisms in exon 2 of CD1 genes are associated with susceptibility to Guillain-Barré syndrome

J Neurol Sci. 2016 Oct 15:369:39-42. doi: 10.1016/j.jns.2016.07.029. Epub 2016 Jul 14.

Abstract

Guillain-Barré syndrome (GBS) is a post-infectious autoimmune peripheral neuropathy. Studies have shown that a T cell-mediated immune response to peripheral nerve is associated with the pathogenesis of GBS. CD1 molecules are MCH-like glycoproteins specialized to capture and present glycolipids to T cells. Polymorphisms of CD1 genes may affect susceptibility to GBS. We investigated the polymorphisms of CD1 genes in GBS patients in a Chinese Han population. In 126 patients and in 138 controls we genotyped exon 2 of the CD1A and CD1E genes. The results indicated that polymorphisms of CD1A genes are associated with GBS. Furthermore, subjects with CD1A*01/02 had a 2.9 times lower risk of developing GBS, and those with CD1A*02/02 had a 2.5 times higher risk to developing GBS than the controls, while there was no association between polymorphisms of CD1E genes and the susceptibilities to GBS.

Keywords: CD1 genes polymorphism; Glycolipid presentation; Guillain–Barré syndrome.

MeSH terms

  • Adolescent
  • Adult
  • Antigens, CD1 / genetics*
  • Child
  • Exons / genetics*
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics*
  • Guillain-Barre Syndrome / genetics*
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic / genetics*
  • Young Adult

Substances

  • Antigens, CD1