Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation

Affiliations

• ¹ Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany.
• ² Institute for Transfusion Medicine, Hannover Medical School, Germany.
• ³ Department. of Nephrology, Medical and Health Science Center, University of Debrecen, Hungary.
• ⁴ MTA-DE Vascular Biology, Thrombosis and Hemostasis Research Group, Hungarian Academy of Sciences Debrecen, Hungary.
• ⁵ Department of Pediatrics, Okayama University Graduate School of Medicine, Japan.
• ⁶ Section of Experimental Anesthesiology, University of Ulm, Germany.
• ⁷ Department of Hematology and Oncology, Children's Hospital, University of Hamburg, Germany.
• ⁸ Institute for Immunology, University Heidelberg, Germany.
• ⁹ Institute of Pathology, University of Heidelberg, Germany.
• ¹⁰ Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Germany andreas.kulozik@med.uni-heidelberg.de martina.muckenthaler@med.uni-heidelberg.de.