Carbon nanotubes (CNTs) are a unique tool in nanotechnology owing to their exceptional properties that offer a variety of opportunities for applications in different fields. Nevertheless, their low dispersibility in organic solvents and in aqueous media hampers their development. The functionalization of their surface allows overcoming this issue, while exploiting and tuning their properties. Thanks to their high specific surface area, multi-functionalization strategies give the possibility to conjugate several copies of different molecules to endow the nanotubes with multiple functionalities. In this context, this review wishes to focus on the preparation of multimodal CNTs designed by covalent multi-functionalization. More specifically, we describe the different approaches that have been developed to prepare multi-functionalized CNTs through double and triple covalent functionalization of the nanotube framework. We also emphasize the strategies used to control the derivatization of multi-functionalized CNTs with molecules of interest mainly via sequential or simultaneous methodologies.