TPMT and NUDT15 genes are both related to mercaptopurine intolerance in acute lymphoblastic leukaemia patients from Uruguay

Br J Haematol. 2018 Apr;181(2):252-255. doi: 10.1111/bjh.14532. Epub 2017 Feb 1.
No abstract available

Keywords: TPMT; NUDT15; 6-Mercaptopurine; Paediatric Acute Lymphoblastic Leukaemia; Pharmacogenetic.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Humans
  • Male
  • Mercaptopurine / adverse effects*
  • Mercaptopurine / therapeutic use
  • Methyltransferases / genetics*
  • Neoplasm Proteins / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Pyrophosphatases / genetics*
  • Uruguay

Substances

  • Neoplasm Proteins
  • Mercaptopurine
  • Methyltransferases
  • TPMT protein, human
  • NUDT15 protein, human
  • Pyrophosphatases