rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride

Hum Psychopharmacol. 2017 Mar;32(2). doi: 10.1002/hup.2562. Epub 2017 Mar 23.

Abstract

A recent genome-wide pharmacogenomics study showed that the rs7968606 single-nucleotide polymorphism (SNP) of the ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B) gene approached the threshold of statistical significance. The aim of this study was to determine the association between the rs7968606 SNP of ANKS1B and the treatment response to amisulpride in schizophrenia patients. In total, 154 participants were enrolled from six university hospitals in Korea. All the subjects were interviewed before and after 6 weeks of amisulpride treatment with the aid of the positive and negative syndrome scale and the clinical global impression-severity scale. Genotyping for the rs7968606 SNP of ANKS1B was performed in 101 subjects. Both the decrease (t = -2.067, p = 0.041) and improvement rate (t = -1.990, p = 0.049) in the positive and negative syndrome scale general score differed significantly between T-allele carriers and noncarriers of this polymorphism after 6 weeks of amisulpride treatment. To the best of our knowledge, this is the first genetic association study of the relationship between the rs7968606 SNP of ANKS1B and the response of schizophrenia patients to treatment with amisulpride. Future larger-scale studies involving more SNPs of ANKS1B will improve the understanding of the pharmacogenetics underlying the treatment responses to amisulpride.

Keywords: ANKS1B gene; amisulpride; antipsychotics; rs7968606; schizophrenia; treatment response.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Amisulpride
  • Antipsychotic Agents / therapeutic use
  • Carrier Proteins / genetics*
  • Double-Blind Method
  • Female
  • Genetic Association Studies
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics
  • Psychiatric Status Rating Scales
  • Schizophrenia / drug therapy*
  • Schizophrenia / genetics*
  • Sulpiride / analogs & derivatives*
  • Sulpiride / therapeutic use
  • Treatment Outcome
  • Young Adult

Substances

  • ANKS1B protein, human
  • Antipsychotic Agents
  • Carrier Proteins
  • Intracellular Signaling Peptides and Proteins
  • Sulpiride
  • Amisulpride