The HIV oligonucleotide database (HIVoligoDB)

João Carneiro; Adriana Resende; Filipe Pereira

doi:10.1093/database/bax005

The HIV oligonucleotide database (HIVoligoDB)

Database (Oxford). 2017 Jan 1;2017(1):bax005. doi: 10.1093/database/bax005.

Authors

João Carneiro¹, Adriana Resende¹, Filipe Pereira

Affiliation

¹ Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leix?Av. General Norton de Matos s/n 4450-208 Porto.

Abstract

The human immunodeficiency virus (HIV) is associated with one of the most widespread infectious disease, the acquired immunodeficiency syndrome (AIDS). The development of antiretroviral drugs and methods for virus detection requires a comprehensive analysis of the HIV genomic diversity, particularly in the binding sites of oligonucleotides. Here, we describe a versatile online database (HIVoligoDB) with oligonucleotides selected for the diagnosis of HIV and treatment of AIDS. Currently, the database provides an interface for visualization, analysis and download of 380 HIV-1 and 65 HIV-2 oligonucleotides annotated according to curated reference genomes. The database also allows the selection of the most conserved HIV genomic regions for the development of molecular diagnostic assays and sequence-based candidate therapeutics.

Database url: http://portugene.com/HIVoligoDB.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acquired Immunodeficiency Syndrome / genetics*
Genome, Viral*
HIV-1 / genetics*
HIV-2 / genetics*
Humans
Oligonucleotides / genetics*

Substances

Oligonucleotides