Doxycycline-tauroursodeoxycholic acid treatment: effects in the heart of a transthyretin V30M transgenic mouse model

Amyloid. 2017 Mar;24(sup1):80. doi: 10.1080/13506129.2016.1277695.
No abstract available

Publication types

  • Letter

MeSH terms

  • Amyloid / antagonists & inhibitors
  • Amyloid / genetics
  • Amyloid / metabolism
  • Amyloid Neuropathies, Familial / drug therapy*
  • Amyloid Neuropathies, Familial / genetics
  • Amyloid Neuropathies, Familial / pathology
  • Animals
  • Biomarkers / blood
  • Cardiomyopathies / drug therapy*
  • Cardiomyopathies / genetics
  • Cardiomyopathies / pathology
  • Collagen Type IV / genetics
  • Collagen Type IV / metabolism
  • Disease Models, Animal
  • Doxycycline / therapeutic use*
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Gene Expression
  • Heart / drug effects*
  • Heart / physiopathology
  • Heat Shock Transcription Factors / deficiency
  • Heat Shock Transcription Factors / genetics
  • Humans
  • Male
  • Mice
  • Mice, Transgenic
  • Mutation
  • Natriuretic Peptide, Brain / blood
  • Peptide Fragments / blood
  • Prealbumin / genetics*
  • Prealbumin / metabolism
  • Ursodeoxycholic Acid / therapeutic use*

Substances

  • Amyloid
  • Biomarkers
  • Collagen Type IV
  • Heat Shock Transcription Factors
  • Hsf1 protein, mouse
  • Peptide Fragments
  • Prealbumin
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain
  • Ursodeoxycholic Acid
  • Doxycycline

Supplementary concepts

  • Amyloidosis, Hereditary, Transthyretin-Related