Exercise as a Positive Modulator of Brain Function

Mol Neurobiol. 2018 Apr;55(4):3112-3130. doi: 10.1007/s12035-017-0516-4. Epub 2017 May 2.

Abstract

Various forms of exercise have been shown to prevent, restore, or ameliorate a variety of brain disorders including dementias, Parkinson's disease, chronic stress, thyroid disorders, and sleep deprivation, some of which are discussed here. In this review, the effects on brain function of various forms of exercise and exercise mimetics in humans and animal experiments are compared and discussed. Possible mechanisms of the beneficial effects of exercise including the role of neurotrophic factors and others are also discussed.

Keywords: Animal voluntary and forced exercise; BDNF; Electrophysiology; Human aerobic and anaerobic exercise; Long-term potentiation; Meditation.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / physiology*
  • Exercise / physiology*
  • Humans
  • Neuroprotection
  • Oxidative Stress
  • Physical Conditioning, Animal*
  • Stress, Physiological

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