Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins

Marjan M Hashemi; John Rovig; Scott Weber; Brian Hilton; Mehdi M Forouzan; Paul B Savage

doi:10.1128/AAC.00292-17

Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins

Antimicrob Agents Chemother. 2017 Jul 25;61(8):e00292-17. doi: 10.1128/AAC.00292-17. Print 2017 Aug.

Authors

Marjan M Hashemi¹, John Rovig¹, Scott Weber¹, Brian Hilton¹, Mehdi M Forouzan², Paul B Savage³

Affiliations

¹ Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
² Department of Chemical Engineering, Brigham Young University, Provo, Utah, USA.
³ Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA pbs@byu.edu.

Abstract

The susceptibility of colistin-resistant clinical isolates of Klebsiella pneumoniae to ceragenins and antimicrobial peptides (AMPs) suggests that there is little to no cross-resistance between colistin and ceragenins/AMPs and that lipid A modifications are found in bacteria with modest changes in susceptibility to ceragenins and with high levels of resistance to colistin. These results suggest that there are differences in the resistance mechanisms to colistin and ceragenins/AMPs.

Keywords: Gram-negative bacteria; antimicrobial peptides; ceragenin; colistin; resistant.

MeSH terms

Acinetobacter baumannii / drug effects*
Anti-Bacterial Agents / pharmacology*
Antimicrobial Cationic Peptides / pharmacology*
Colistin / pharmacology*
Drug Resistance, Multiple, Bacterial
Humans
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / isolation & purification
Lipid A / genetics
Microbial Sensitivity Tests
Pseudomonas aeruginosa / drug effects*
Steroids / pharmacology*

Substances

Anti-Bacterial Agents
Antimicrobial Cationic Peptides
Lipid A
Steroids
ceragenin CSA-13
Colistin