New Insights into Genome Structure: Genes of a Feather Stick Together

Denes Hnisz; Richard A Young

doi:10.1016/j.molcel.2017.08.023

New Insights into Genome Structure: Genes of a Feather Stick Together

Mol Cell. 2017 Sep 7;67(5):730-731. doi: 10.1016/j.molcel.2017.08.023.

Authors

Denes Hnisz¹, Richard A Young²

Affiliations

¹ Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
² Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: young@wi.mit.edu.

Abstract

DNA structuring proteins such as CTCF facilitate DNA loop formation and are presumed to be among the major determinants of eukaryotic genome structure. Recent studies, including Rowley et al. (2017), suggest that gene activation and repression play fundamentally important roles in structuring the genome independently of CTCF.

MeSH terms

DNA
DNA-Binding Proteins / genetics*
Genome
Repressor Proteins / genetics*

Substances

DNA-Binding Proteins
Repressor Proteins
DNA

Grants and funding

R01 HG002668/HG/NHGRI NIH HHS/United States