Refractory Pseudomonas Bacteremia in a 2-Year-Old Sterilized by Bacteriophage Therapy

C Duplessis; B Biswas; B Hanisch; M Perkins; M Henry; J Quinones; D Wolfe; L Estrella; T Hamilton

doi:10.1093/jpids/pix056

Refractory Pseudomonas Bacteremia in a 2-Year-Old Sterilized by Bacteriophage Therapy

J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):253-256. doi: 10.1093/jpids/pix056.

Authors

C Duplessis¹, B Biswas^{2

3}, B Hanisch^{4

5}, M Perkins⁶, M Henry², J Quinones², D Wolfe², L Estrella², T Hamilton²

Affiliations

¹ Enteric Disease Department, Infectious Disease Directorate, Naval Medical Research Center, Silver Spring, Maryland.
² Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, Maryland.
³ Henry M. Jackson Foundation, Bethesda, Maryland.
⁴ Pediatric Infectious Diseases, Children's National Medical Center, Washington, DC.
⁵ Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC.
⁶ Walter Reed National Military Medical Center, Bethesda, Maryland.

PMID: 28992111
DOI: 10.1093/jpids/pix056

Abstract

Here, we report a complex case that involved a pediatric patient who experienced recalcitrant multidrug-resistant Pseudomonas aeruginosa infection complicated by bacteremia/sepsis; our antibacterial options were limited because of resistance, allergies, and suboptimal source control. A cocktail of 2 bacteriophages targeting the infectious organism introduced on 2 separate occasions sterilized the bacteremia.

Publication types

Case Reports

MeSH terms

Bacteremia / blood
Bacteremia / therapy*
Child, Preschool
Drug Resistance, Multiple, Bacterial
Fatal Outcome
Humans
Male
Phage Therapy* / adverse effects
Phage Therapy* / methods
Pseudomonas Infections / blood
Pseudomonas Infections / therapy*