miR-1260b promotes cell migration and invasion of hepatocellular carcinoma by targeting the regulator of G-protein signaling 22

Biotechnol Lett. 2018 Jan;40(1):57-62. doi: 10.1007/s10529-017-2455-6. Epub 2017 Oct 16.

Abstract

Objectives: To investigate whether miR-1260b can regulate migration and invasion of hepatocellular carcinoma (HCC) by targeting RGS22.

Results: miR-1260b was up-regulated in HCC tissues compared with their corresponding non-cancerous tissues. Over-expression of miR-1260b increased migration and invasion of HepG2 and SMMC-7721 cells associated with HCC. Regulator of G-protein signaling 22 (RGS22) was identified as a directly target of miR-1260b and was inhibited by miR-1260b. Knockdown of RGS22 increased proliferation of HCC cells.

Conclusions: The new identified miR-1260b/RGS22 axis provides useful therapeutic methods for treatment of HCC deepening on our understanding of underlying mechanisms of HCC tumorigenesis.

Keywords: G Protein-coupled receptors; Hepatocellular carcinoma; Invasion; MIR-1260B; Migration; RGS22.

MeSH terms

  • Antigens, Surface / metabolism*
  • Carcinoma, Hepatocellular / pathology*
  • Carcinoma, Hepatocellular / physiopathology
  • Cell Movement*
  • Cell Proliferation*
  • GTP-Binding Protein Regulators / metabolism*
  • Hep G2 Cells
  • Humans
  • Liver Neoplasms / pathology*
  • Liver Neoplasms / physiopathology
  • MicroRNAs / metabolism*
  • Signal Transduction

Substances

  • Antigens, Surface
  • GTP-Binding Protein Regulators
  • MIRN1260 microRNA, human
  • MicroRNAs
  • regulator of G-protein signaling 22, human