Screening of Patients at Risk for Familial Pancreatic Cancer: What Is Beneficial?

Surg Clin North Am. 2018 Feb;98(1):25-35. doi: 10.1016/j.suc.2017.09.003.

Abstract

Family history is a significant risk factor for developing pancreatic cancer and this hereditary risk can be secondary to familial cancer predisposition syndromes, hereditary pancreatitis, or familial pancreatic cancer. Certain high-risk individuals are recommended to undergo screening for pancreatic cancer with endoscopic ultrasound or MRI/magnetic resonance retrograde cholangiopancreatography because of the potential to identify and curatively resect precursor lesions. The management of suspicious lesions identified on screening high-risk individuals is also discussed.

Keywords: Familial pancreatic cancer; High-risk individuals; Pancreatic cancer; Screening; Surveillance.

Publication types

  • Review

MeSH terms

  • Carcinoma* / diagnosis
  • Carcinoma* / epidemiology
  • Carcinoma* / genetics
  • Early Detection of Cancer*
  • Genetic Predisposition to Disease*
  • Genetic Testing
  • Humans
  • Incidence
  • Neoplastic Syndromes, Hereditary* / diagnosis
  • Neoplastic Syndromes, Hereditary* / epidemiology
  • Neoplastic Syndromes, Hereditary* / genetics
  • Pancreatic Neoplasms* / diagnosis
  • Pancreatic Neoplasms* / epidemiology
  • Pancreatic Neoplasms* / genetics
  • Risk Assessment
  • United States / epidemiology

Supplementary concepts

  • Pancreatic carcinoma, familial