30 s Response Time of K+ Ion-Selective Hydrogels Functionalized with 18-Crown-6 Ether Based on QCM Sensor

Zhenxiao Zhang; Qian Dou; Hongkai Gao; Bing Bai; Yongmei Zhang; Debo Hu; Ali K Yetisen; Haider Butt; Xiaoxia Yang; Congju Li; Qing Dai

doi:10.1002/adhm.201700873

30 s Response Time of K⁺ Ion-Selective Hydrogels Functionalized with 18-Crown-6 Ether Based on QCM Sensor

Adv Healthc Mater. 2018 Mar;7(5). doi: 10.1002/adhm.201700873. Epub 2017 Dec 6.

Authors

Zhenxiao Zhang^{1

2}, Qian Dou¹, Hongkai Gao³, Bing Bai¹, Yongmei Zhang³, Debo Hu¹, Ali K Yetisen⁴, Haider Butt^{5

6}, Xiaoxia Yang¹, Congju Li⁷, Qing Dai¹

Affiliations

¹ Division of Nanophotonics, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.
² College of Material Science and Engineering, Beijing Institute of Fashion Technology, Beijing, 10029, China.
³ The Armed Police General Hospital, Beijing, 100039, China.
⁴ Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA, 02139, USA.
⁵ Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
⁶ University of Birmingham, Birmingham, B15 2TT, UK.
⁷ Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, National Center for Nanoscience and Technology (NCNST), Beijing, 100083, P. R. China.

PMID: 29210514
DOI: 10.1002/adhm.201700873

Abstract

Potassium detection is critical in monitoring imbalances in electrolytes and physiological status. The development of rapid and robust potassium sensors is desirable in clinical chemistry and point-of-care applications. In this study, composite supramolecular hydrogels are investigated: polyethylene glycol methacrylate and acrylamide copolymer (P(PEGMA-co-AM)) are functionalized with 18-crown-6 ether by employing surface initiated polymerization. Real-time potassium ion monitoring is realized by combining these compounds with quartz crystal microbalance. The device demonstrates a rapid response time of ≈30 s and a concentration detection range from 0.5 to 7.0 × 10^-3 m. These hydrogels also exhibit high reusability and K⁺ ion selectivity relative to other cations in biofluids such as Na⁺ , NH₄⁺ , Mg²⁺ , and Ca²⁺ . These results provide a new approach for sensing alkali metal ions using P(PEGMA-co-AM) hydrogels.

Keywords: QCM sensors; potassium detection; supramolecular hydrogels.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Crown Ethers / chemistry*
Hydrogels / chemistry*
Methacrylates / chemistry*
Polyethylene Glycols / chemistry*
Potassium / chemistry*
Quartz Crystal Microbalance Techniques*

Substances

Crown Ethers
Hydrogels
Methacrylates
polyethylene glycol methacrylate
Polyethylene Glycols
18-crown-6
Potassium