Enhancing the performance of brewing yeasts

Biotechnol Adv. 2018 May-Jun;36(3):691-706. doi: 10.1016/j.biotechadv.2017.12.014. Epub 2017 Dec 22.

Abstract

Beer production is one of the oldest known traditional biotechnological processes, but is nowadays facing increasing demands not only for enhanced product quality, but also for improved production economics. Targeted genetic modification of a yeast strain is one way to increase beer quality and to improve the economics of beer production. In this review we will present current knowledge on traditional approaches for improving brewing strains and for rational metabolic engineering. These research efforts will, in the near future, lead to the development of a wider range of industrial strains that should increase the diversity of commercial beers.

Keywords: Beer; Brewing yeasts; Genetic engineering; Metabolic engineering; Saccharomyces cerevisiae; Saccharomyces pastorianus; Strain improvement.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Beer*
  • CRISPR-Cas Systems
  • Fermentation
  • Gene Expression Regulation, Fungal
  • Genetic Engineering / methods*
  • Genome, Fungal
  • Humans
  • Metabolic Engineering / methods*
  • Microorganisms, Genetically-Modified / genetics*
  • Microorganisms, Genetically-Modified / physiology
  • Plasmids / genetics
  • Public Opinion
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / physiology