Novel SCCmec type XIII (9A) identified in an ST152 methicillin-resistant Staphylococcus aureus

Infect Genet Evol. 2018 Jul:61:74-76. doi: 10.1016/j.meegid.2018.03.013. Epub 2018 Mar 19.

Abstract

We identified a novel staphylococcal cassette chromosome mec (SCCmec) element in an ST152 methicillin-resistant Staphylococcus aureus (MRSA) isolate by combining Illumina and MinION sequencing. The element contains a new ccrC allotype designated ccrC2. The mec complex resembles mec class A, but with an altered organization of the genes. The element was acknowledged as novel by the International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC) and designated SCCmec type XIII (9A).

Keywords: Antibiotic resistance; Evolution; MRSA; Mobile genetic element; SCCmec; Staphylococcus aureus.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bacterial Proteins / genetics*
  • DNA, Bacterial / genetics*
  • Genes, Bacterial / genetics
  • Humans
  • Male
  • Methicillin Resistance / genetics
  • Methicillin-Resistant Staphylococcus aureus / genetics*
  • Penicillin-Binding Proteins / genetics*
  • Phylogeny
  • Staphylococcal Infections / microbiology*

Substances

  • Bacterial Proteins
  • DNA, Bacterial
  • Penicillin-Binding Proteins
  • mecA protein, Staphylococcus aureus