Abstract
Skin biopsies from US leprosy patients were tested for mutations associated with drug resistance. Dapsone resistance was found in 4 of 6 biopsies from American Samoa patients. No resistance was observed in patients from other origins. The high rate of dapsone resistance in patients from American Samoa warrants further investigation.
Keywords:
American Samoa; Mycobacterium leprae; National Hansen’s Disease Programs; United States; antimicrobial resistance; bacteria; dapsone resistance; folP1; leprosy; rifampin; rpoB; tuberculosis and other mycobacteria.
MeSH terms
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American Samoa
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Biopsy
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Clofazimine / therapeutic use
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Dapsone / therapeutic use*
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Drug Administration Schedule
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Drug Resistance, Bacterial / genetics*
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Genes, Bacterial*
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Humans
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Leprostatic Agents / therapeutic use*
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Leprosy / diagnosis
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Leprosy / drug therapy*
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Leprosy / microbiology
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Microbial Sensitivity Tests
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Mutation
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Mycobacterium leprae / classification
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Mycobacterium leprae / drug effects*
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Mycobacterium leprae / genetics*
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Mycobacterium leprae / isolation & purification
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Rifampin / therapeutic use
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Skin / drug effects
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Skin / microbiology
Substances
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Leprostatic Agents
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Dapsone
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Clofazimine
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Rifampin