Angio-LncRs: LncRNAs that regulate angiogenesis and vascular disease

Theranostics. 2018 Jun 8;8(13):3654-3675. doi: 10.7150/thno.26024. eCollection 2018.

Abstract

Long noncoding RNAs (lncRNAs) represent a large subgroup of RNAs that are longer than 200 nucleotides and have no apparent protein coding potential. They have diverse functions in different biological processes by regulating chromatin remodeling or protein translation. This review summarizes the recent progress of lncRNAs in angiogenesis and vascular diseases. A general overview of lncRNA functional mechanisms will be introduced. A list of lncRNAs, which are termed "Angio-LncRs", including MALAT1, MANTIS, PUNISHER, MEG3, MIAT, SENCR and GATA6-AS, will be discussed regarding their expression, regulation, function and mechanism of action in angiogenesis. Implications of lncRNAs in vascular diseases, such as atherosclerosis, hypertension, vascular retinopathies and tumor angiogenesis will also be discussed.

Keywords: Angio-LncR; angiogenesis; atherosclerosis; hypertension; lncRNA; retinopathy; vascular disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Vessels / pathology*
  • Blood Vessels / physiology*
  • Humans
  • Neovascularization, Pathologic*
  • Neovascularization, Physiologic*
  • RNA, Long Noncoding / metabolism*
  • Vascular Diseases / pathology*
  • Vascular Diseases / physiopathology*

Substances

  • RNA, Long Noncoding