Dissecting plant hormone signaling with synthetic molecules: perspective from the chemists

Shinya Hagihara; Ryotaro Yamada; Kenichiro Itami; Keiko U Torii

doi:10.1016/j.pbi.2018.09.002

Dissecting plant hormone signaling with synthetic molecules: perspective from the chemists

Curr Opin Plant Biol. 2019 Feb:47:32-37. doi: 10.1016/j.pbi.2018.09.002. Epub 2018 Sep 21.

Authors

Shinya Hagihara¹, Ryotaro Yamada², Kenichiro Itami², Keiko U Torii³

Affiliations

¹ Center for Sustainable Resource Science (CSRS), RIKEN, Wako, Saitama, Japan; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya 464-8601, Japan; PRESTO, JST, Japan; Department of Chemistry, Graduate School of Science, Nagoya University, Japan. Electronic address: hagi@itbm.nagoya-u.ac.jp.
² Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya 464-8601, Japan; Department of Chemistry, Graduate School of Science, Nagoya University, Japan.
³ Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya 464-8601, Japan; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195-1800, USA; Department of Biology, University of Washington, Seattle, WA 98195-1800, USA. Electronic address: ktorii@u.washington.edu.

PMID: 30248557
DOI: 10.1016/j.pbi.2018.09.002

Abstract

Synthetic molecules can be powerful tools to overcome the limitations of the biological approaches. Especially redundancy, lethality, and intractability of the target genes, which often hamper the progress of plant science, could be bypassed by elaborately designed small molecules. In this review, we discuss how synthetic chemistry can contribute to increasing our understanding of plant hormone signaling. Specific focus will be on the visualization and hijacking of hormone signaling with novel synthetic chemicals, with emphasis on perception of ABA, strigolactones, and auxins.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Chemistry*
Fluorescent Dyes / metabolism
High-Throughput Screening Assays
Plant Growth Regulators / metabolism*
Receptors, Cell Surface / metabolism
Signal Transduction*

Substances

Fluorescent Dyes
Plant Growth Regulators
Receptors, Cell Surface